文章摘要
魏凯峰,常加松,张梅勇,张庆宏,潘云.升降散对急性肺损伤大鼠肺细支气管粘膜上皮细胞ICAM-1表达的影响[J].江西中医药大学学报,2007,(3):55-57. |
升降散对急性肺损伤大鼠肺细支气管粘膜上皮细胞ICAM-1表达的影响 |
Effect of Shengjiang Powder on Expression of ICAM-1 of Lung Bronchiolar Epithelium Mucosae in Acute Lung Injury Rats |
投稿时间:2007-05-17 修订日期:2007-05-17 |
DOI: |
中文关键词: 升降散 急性肺损伤 肺细支气管粘膜上皮细胞 ICAM-1 |
英文关键词: Shengjiang Powder;Acute lung injury;Lung bronchiolar epithelium mucosae;Expression of ICAM-1 |
基金项目:南京中医药大学校自然科学基金(No.05XZK01) |
魏凯峰,常加松,张梅勇,张庆宏,潘云 |
南京中医药大学,南京210029 |
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中文摘要: |
目的:探讨升降散对急性肺损伤模型大鼠细气管粘膜上皮ICAM-1表达的影响。方法:40只雄性SD大鼠,随机分为正常组、模型组、升降散大剂量组、中剂量组及小剂量组。给药6天后,舌下静脉注射LPS复制急性肺损伤模型,取肺组织切片,免疫组化检测。采集图像,分析细支气管粘膜上皮细胞胞质的平均灰度。结果:药物治疗组与模型组比较,能明显抑制肺细气管粘膜上皮细胞胞质ICAM-1的表达,有显著性差异。结论:升降散可通过抑制肺细气管粘膜上皮细胞胞质ICAM-1的表达,抑制炎症反应对肺组织造成的急性损伤,对急性肺损伤起到防治作 |
英文摘要: |
Objective:To investigate the effect of Shengjiang Powder on expression of ICAM-1 of lung bronchiolar epithelium mucosae in acute lung injury rats.Methods:Totally 40 healthy SD male rats of which were divided into 5 groups by random:control group,model group,Shengjiang powder high-,low-and middle-dose groups.At the 6th day after administration,reproduce acute lung injury rat models by injecting LPS into sublingual vein.Detected the expression of ICAM-1 by assessing lung histological sections by immmunohistochemistry.Capture the images and measured the average gray values of cytoplasm of lung bronchiolar epithelium mucosae.Results:Compared with model group,Shengjiang Powder could depress the expression of ICAM-1 in the cytoplasm of lung bronchiolar epithelium mucosae,statistical difference existed between treating groups and model group.Conclusion:Shengjiang Powder can preventing and treating acute lung injury by inhibiting inflammatory damage on lung tissues through depressing the expression of ICAM-1 in the cytoplasm of lung bronchiolar epithelium mucosae. |
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