文章摘要
| 刘建群,吴继梅,张锐.扁担杆化学成分体外抑菌活性研究[J].江西中医药大学学报,2009,21(2):75-76. |
| 扁担杆化学成分体外抑菌活性研究 |
| Study on the in vitro antibacterial activities of compounds isolated from Grewia biloba |
| 投稿时间：2009-02-27 |
| DOI： |
| 中文关键词: 扁担杆；抗菌；儿茶素；液体两倍稀释法 |
| 英文关键词: Grewia biloba; Antibacterial activity; catechin; Double dilution method |
| 基金项目:基金项目：江西省卫生厅中医药科研基金项目(2007A094) |
| 刘建群,吴继梅,张锐 |
| 江西中医学院现代中药制剂教育部重点实验室,南昌330004 |
| 摘要点击次数: 5255 |
| 全文下载次数: 5687 |
| 中文摘要: |
| 目的：寻找药用植物扁担杆的抗菌活性成分。方法：将从扁担杆中分得的6个化合物：木栓酮(1)、表木栓醇(2)、二十一酸(3)、β-谷甾醇(4)、棕榈酸丙酯(5)、儿茶素(6)，采用液体两倍稀释法对金黄色葡萄球菌、大肠杆菌、绿脓杆菌、β-溶血性链球菌、表皮葡萄球菌、柠檬色葡萄球菌进行体外抑菌实验。结果：与阳性对照药盐酸小檗碱比较，上述6个化合物对除金黄色葡萄球菌以外的5种细菌生长均有明显的抑制作用，特别是儿茶素对绿脓杆菌、β-溶血性链球菌和表皮葡萄球菌均有较强的抑制作用，最低抑菌浓度分别为0.004、0.002 |
| 英文摘要: |
| Objective To screen the antibacterial constituents from Grewia biloba.Methods Double dilution method was used to determine the minimum inhibitory concentration (MIC) of six compounds,friedelin (1),epi-friedelan-3-ol (2),heneicosanoic acid(3),β-sitosterol (4),Propyl palmitate (5),catechin (6),isolated from Grewia biloba against Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,β-Hemolytic streptococcus,Staphylococcus epidermidis and Staphylococcus citreus.Results Compounds 1-6 can obviously inhibit the growth of the above five bacteria except for Staphylococcus aureus.Furthermore catechin (6) showed stronger antibacterial activities than berberine hydrochloride against Pseudomonas aeruginosa,β-Hemolytic streptococcus and Staphylococcus epidermidis with MIC 0.004、0.002、0.004 mg/ml,respectively.Conclusion Compounds 1-6 isolated from Grewia biloba have obvious antibacterial activities and catechin (6) showed strong antibacterial activities. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
|
|